Immunology Services

Dr. Kelli Williams speaking with another care team member.

At MUSC Children’s Health’s Immunology Clinic, our goal is to provide children and their families with individualized treatment plans for their immunologic conditions. Our clinic at the MUSC Children’s Health R. Keith Summey Medical Pavilion has radiology (imaging services), phlebotomy (lab services) and consultation services on site.

What is an immunologic condition?

An immunologic condition is a disruption in the immune system, which can make a person sick. The disruptions may be caused by the person not having enough cells to fight an infection, or the cells they have may not work the way they are supposed to, or the cells get confused and no longer function properly. Most commonly, patients present with frequent infections, severe and/or hard to treat infections, or unusual infections.

There are three main types of immunologic conditions:

  1. Primary Immune Deficiency – conditions that are caused by defects in a person’s genes so often present early in life
  2. Secondary Immune Deficiency – conditions that occur when the immune system is compromised due to one or more environmental factors, such as medications, infections, and procedures
  3. Primary Immune regulatory disorders – conditions that are caused by immune cells leading to organ damage and inflammation

Who is affected by immunologic conditions?

Anyone can be affected by immunologic conditions. Some people are born with them and some people develop them after birth. They can occur at any age.

What should I look out for if I suspect my child may have primary immunodeficiency (PI)?

10 Warning Signs of PI in children, per the Jeffrey Modell Foundation:

  1. Four or more new ear infections within 1 year
  2. Two or more serious sinus infections within 1 year
  3. Two or more months on antibiotics with little effect
  4. Two or more pneumonias within 1 year
  5. Failure of an infant to gain weight or grow normally
  6. Recurrent, deep skin or organ abscesses
  7. Persistent thrush in mouth or fungal infection on skin
  8. Need for intravenous antibiotics to clear infections
  9. Two or more deep-seated infections including septicemia
  10. A family history of PI

If you suspect your child may be affected by two or more of the 10 warning signs, make an appointment with your physician.

Services We Offer

  • Prophylactic Antibiotics
  • IVIG (intravenous immunoglobulin therapy)
  • SCIG (subcutaneous immunoglobulin therapy)
  • Hematopoietic stem cell transplantation (HSCT)

Immunology Conditions We Treat

  • Recurrent infections
  • Hypogammaglobulinemia or low antibody levels
  • Lymphopenia or low white blood cell count (WBC)
  • Neutropenia or low absolute neutrophil count (ANC)
  • Early onset inflammatory bowel disease (IBD)
  • Recurrent fevers
  • CVID (Common Variable Immune Deficiency)
  • DiGeorge syndrome
  • SCID (Severe Combined Immune Deficiency)

MUSC Children’s Health providers are actively involved in many national and international clinical immunology organizations, including: Clinical Immunology Society (CIS), Immune Deficiency Foundation (IDF), American Academy of Allergy, Asthma and Immunology (AAAAI) and Jeffrey Modell Foundation (JMF)



Immunology at Summey Medical Pavilion

R. Keith Summey Medical Pavilion
2250 Mall Drive
North Charleston, SC 29406